MidgeBase gene description page [Pn.04314]
Outline
| Gene ID | Pn.04314 |
| Type | Protein coding gene |
| Scaffold | PnScaf3543 |
| Start | 28587 |
| End | 35811 |
| Direction | + |
Sequence
Transcript: 1923 (bp)
ATGGGAAATGCAGTTTCAATTTGTCGTCAAAAGAGAGTCGCAACGGAAAATGAAAATGAAAATCACGATGTAATGAGCAATAGTGAGCGCTTCAAATATAAAACGCAGACGAATGAAAATTTTCTCAGTCAGAATAATTCAGTCGACCACAACACATCGGTTGTTGAAAAAATTCAAGTTCTGTCGTCATTTGAGTTGAACAATACGAAATCGAACATCATGAGTGAGTGCAGAGATAGACTTGGACAATTTCCCTTTGCGAGTGACAGCGAGTTGCCGGGAACGGGCCTTCAACGTCTGAAAAATGGAAAATTCAATAAGGGCCTTGGCTTTACTCGCGAGGAGCGTCAGGTTTTGGGAATTCACGGATTGCTCGCACCGGCTCTGAGAAGCGAGGAGGATCAAGTGAAGCACGCTCACTTGCTCTTGGAGCGATGTGCCACTGACTTAGATAGATACATTTACTTGATGGGACTTCAAGATCGCAACGAGCGCCTCTTTTATCGCGTTCTTGCTTCAGATATCGGAAACATGATGCCTCTAGTTTACACCCCAGTAGTCGGCCTCGCCTGTCAAAAGTTTTCGTCGATTTACACAAACCCAAAGGGTCTCTACATCACAATCTACGACAAGGGCCACGTCTATGACGTCCTCAAGAACTGGCCGGAGCGCGACGTTCGCGCAATCGTCGTGACCGACGGCGAGAGAATTCTCGGTCTGGGCGATCTTGGCGCGAACGGCATGGGAATCCCGGTCGGCAAGTTGGCTCTTTACACGGCACTCGCCGGAATCAAGCCGCACCAATGCCTGCCCATCACTCTCGACGTCGGCACTAACACGCAGTCGATTCTGGACGATCCACTGTACATCGGACTGCGTCAGAAGCGCGTGACCGGCCAGGAGTACGACGACTTCGTCGAGGAGTTCATGCAAGCAGCCGTTCGTCGCTTCGGCCAGAACTGCCTCATTCAGTTCGAGGATTTCGGCAATTCGAACGCGTTCCGTCTGCTCGAGAAGTACCGCGACCACTACTGCACGTTCAACGACGACATTCAGGGAACGGCTTCAGTGGCCGTTGCCGGTCTGCTGGCCTCGCTGCGCGTCACAAAGACACGCTTGTCGGACAACAAAATTCTGTTCCAGGGAAGCGGAGAAGCCGCCCTCGGAATCGCCGAGTTGTGCGTGATGGCAATGATTCGAGAGGGAATCTGCGAGGAGGACGCCCGCTCGCGCGTCTGGCTCGTCGACAGCAAGGGACTGATCGTTAAGGACCGTCCCAAAGGAGGCCTCAACCATCACAAGAACAAGTTTGCTCACGCTCATCCACCAGTCGACACCTTGACCGAAGCCGTCAACATTCTTAAGCCGACCGTTCTGATCGGAGCCGCTGCCATTGGTGGCGCATTCACTCCCGAAATCATCCAGCGTATGGCAGAGTTCAACGAGCGCCCAATCATTTTTGCGCTCTCAAATCCAACCAGCAAGGCCGAGTGCACGGCCGAAGACGCATACAAGTACAGCAATGGAAAGGCCGTTTTCGCTTCTGGCTCACCGTTCGCTCCCGTCACATTCAACGGACAGACTTTCTACCCTGGACAGGGAAACAACTCGTACATCTTCCCCGGAGTCGCTCTGGGCGTCATCTGCGGTGCCGTGTCCGTCATTCCCGAAGACATTTTCCTCATGTCTGCGAAGGCACTTGCTGATCTTGTCACTGACGACGACCTAAGCAAAGGCTCGCTTTATCCACCACTGGAAATGATTCAGGATTGCTCACTTGAAATTGCCGAGAAGGTCATAGAATACGCCTACGAAAAGGGACTCGCTACCGTTCGTCCAAAGCCCGAGAACATCCACGAATTCATCAAGGCTCAAATGTACGACACCACATACAAATCTGCAATTCCACCCGTATACAAATTC
Protein: 641 (aa)
MGNAVSICRQKRVATENENENHDVMSNSERFKYKTQTNENFLSQNNSVDHNTSVVEKIQVLSSFELNNTKSNIMSECRDRLGQFPFASDSELPGTGLQRLKNGKFNKGLGFTREERQVLGIHGLLAPALRSEEDQVKHAHLLLERCATDLDRYIYLMGLQDRNERLFYRVLASDIGNMMPLVYTPVVGLACQKFSSIYTNPKGLYITIYDKGHVYDVLKNWPERDVRAIVVTDGERILGLGDLGANGMGIPVGKLALYTALAGIKPHQCLPITLDVGTNTQSILDDPLYIGLRQKRVTGQEYDDFVEEFMQAAVRRFGQNCLIQFEDFGNSNAFRLLEKYRDHYCTFNDDIQGTASVAVAGLLASLRVTKTRLSDNKILFQGSGEAALGIAELCVMAMIREGICEEDARSRVWLVDSKGLIVKDRPKGGLNHHKNKFAHAHPPVDTLTEAVNILKPTVLIGAAAIGGAFTPEIIQRMAEFNERPIIFALSNPTSKAECTAEDAYKYSNGKAVFASGSPFAPVTFNGQTFYPGQGNNSYIFPGVALGVICGAVSVIPEDIFLMSAKALADLVTDDDLSKGSLYPPLEMIQDCSLEIAEKVIEYAYEKGLATVRPKPENIHEFIKAQMYDTTYKSAIPPVYKF
| Type | Start | End | Length |
| CDS |
28587 |
28621 |
35 |
| CDS |
30280 |
30565 |
286 |
| CDS |
33829 |
34033 |
205 |
| CDS |
34223 |
35391 |
1169 |
| CDS |
35581 |
35808 |
228 |
| intron |
28622 |
30279 |
1658 |
| intron |
30566 |
33828 |
3263 |
| intron |
34034 |
34222 |
189 |
| intron |
35392 |
35580 |
189 |
Auto annotation result
| Program/Analysis | Accession | Description | Score/Expectation |
| BLASTP/NCBI-nr |
XP_001651437 |
malic enzyme [Aedes aegypti] gb|EAT42717.1| malic enzyme [Aedes aegypti] |
0.0 |
| InterPro |
IPR001891 |
Malic oxidoreductase |
|
| InterPro |
IPR012302 |
Malic enzyme, NAD-binding |
|
| InterPro |
IPR015884 |
Malic enzyme, conserved site |
|
| InterPro |
IPR012301 |
Malic enzyme, N-terminal |
|
| InterPro |
IPR016040 |
NAD(P)-binding domain |
|
| Gene Ontology(BP) |
GO:0055114 |
oxidation-reduction process |
|
| Gene Ontology(BP) |
GO:0006108 |
malate metabolic process |
|
| Gene Ontology(MF) |
GO:0016619 |
malate dehydrogenase (oxaloacetate-decarboxylating) activity |
|
| Gene Ontology(MF) |
GO:0046872 |
metal ion binding |
|
| Gene Ontology(MF) |
GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
|
| Gene Ontology(MF) |
GO:0004470 |
malic enzyme activity |
|
| Gene Ontology(MF) |
GO:0000166 |
nucleotide binding |
|
| Gene Ontology(MF) |
GO:0051287 |
NAD binding |
|
| Gene Ontology(MF) |
GO:0016491 |
oxidoreductase activity |
|
| Pfam |
PF03949.10 |
Malic enzyme, NAD binding domain |
5e-90 |
| Pfam |
PF00390.14 |
Malic enzyme, N-terminal domain |
1.5e-79 |
Expression level (RPKM)
Paralog/Ortholog genes
Paralogous genes
Orthologous genes
| Species |
Gene ID |
| H. melpomene |
HMEL007906-PA |
| H. sapiens |
ENSP00000440246 |
| C. quinquefasciatus |
CPIJ012341 |
| S. invicta |
SI2.2.0_11289 |
| D. melanogaster |
FBgn0029154 |
| D. melanogaster |
FBgn0029153 |
| H. sapiens |
ENSP00000376998 |
| C. quinquefasciatus |
CPIJ009608 |
| A. aegypti |
AAEL001073 |
| C. quinquefasciatus |
CPIJ009607 |
| M. musculus |
ENSMUSG00000032418 |
| H. melpomene |
HMEL008370-PA |
| H. sapiens |
ENSP00000352657 |
| B. mori |
BGIBMGA006246-TA |
| H. sapiens |
ENSP00000431182 |
| D. plexippus |
DPOGS208229PA |
| A. gambiae |
AGAP004159 |
| H. sapiens |
ENSP00000321070 |
| H. sapiens |
ENSP00000446114 |
| A. mellifera |
GB16951-PA |
| N. vitripennis |
NV16370-PA |
| A. mellifera |
GB17291-PA |
| P. vanderplanki |
Pv.05872 |
| D. plexippus |
DPOGS211597PA |
| B. mori |
BGIBMGA006419-TA |
| D. melanogaster |
FBgn0029155 |
| B. mori |
BGIBMGA006247-TA |
| A. aegypti |
AAEL001091 |
| M. musculus |
ENSMUSG00000030621 |
| T. castaneum |
TC005232 |
| M. musculus |
ENSMUSG00000024556 |
| A. gambiae |
AGAP000184 |
| A. aegypti |
AAEL005790 |
| H. sapiens |
ENSP00000439912 |
| H. sapiens |
ENSP00000433636 |
| H. sapiens |
ENSP00000315255 |
| N. vitripennis |
NV10467-PA |
| T. castaneum |
TC005233 |
| H. sapiens |
ENSP00000372384 |
| H. sapiens |
ENSP00000358719 |
| P. vanderplanki |
Pv.15499 |
| D. melanogaster |
FBgn0002719 |
| P. humanus |
PHUM268250-PA |