MidgeBase gene description page [Pn.02274]
Outline
| Gene ID | Pn.02274 |
| Type | Protein coding gene |
| Scaffold | PnScaf1923 |
| Start | 12331 |
| End | 22599 |
| Direction | + |
Sequence
Transcript: 2937 (bp)
ATGATGAAAAACTTAACATTTTTCTCCAAAATTCAATGCAAACTAACGGATTGTACGCAACAGAAGCTGATGACAGACAAGAAGACTTTGGAGAAGACATGGAAGCTGATGGACAAAGTGGTGAAGCTGTGTCAACAGAGCAAGATGAACCTCAAAAACAGTCCGCCATTCATTCTTGACATCCTGCCCGATACGTACCAGCGCTTACATTTAATTTACTCAAAATACGAAGACCAAATGCACGTTCTACATAGCAATGAACATTTTACCGTATTTATAAATAATTTAATGCGAAAGTGCAAGCAGGCAATTAAGCTGTTCAAGGAGGGTAAAATGCAGATGTTCGACGAGAATTCGCACTATCGTCGCAACCTCACGAAACTTAGTCTAGTGTTCTCGCATATGCTGAGCGAATTGAAGGCTATCTTCCCCAATGGCACCTTCGCCGGAGACCAATTTCGTATTACAAAGGCCGATGCGGCCGAGTTTTGGAAGTCTCGTTTCGGAAACAATACACTCGTGCAATGGAAGACGTTTCGAGCTCATCTCTCCGAGGTACATCCAATATCGTCGGGCCTGGAGGCGATGGCATTGAAAACGACTATAGACTTAACATGCAATGATTATATATCAAATTTTGAATTTGACGTATTTACAAGACTCTTCCAACCTTGGAACACGCTGTTGAGGAACTGGCAAATATTAGCCGTCACCCATCCCGCATATGTGGCATTTCTCACATACGATGAAGTCAAAGCTAGATTACAAAAATACATAAATAAGGCTGGTAGTTACGTATTTAGATTATCGTGTACGCGTTTAGGTCAATGGGCCATCGGCTATGTCACGGCCGATGGCGAGATTCTACAAACAATTCCACAAAACAAATCACTATGTCAAGCGCTCCTCGACGGATATCGAGAGGGCTTCTATCTCTATCCCGACGGCCGACCGCACAATCCTGATTTATCGTTCGCTGTACAGAGTCCATTAGAGGATCACATAACCGTGACACAAGAACAATATGAGCTTTATTGTGAAATGGGAAGCACCTTTCAATTGTGTAAAATATGTGCGGAGAATGACAAAGATATTCGCATCGAGCCGTGTGGACATTTGTTATGCACACCGTGTCTTACGGCGTGGCAAGTCGACTCGGAGGGTCAGGGCTGTCCGTTCTGTAGGGCGGAGATCAAAGGAACTGAGCAAATTATAGTCGACGCATTCGATCCGCAACGACAGTACAATCGGAATAGCAAACAAAAAGATGAGGATCATGATGATGAAAATGAGGAAACGGAATTTAATCTCGAAGAGTCATCCATACAAGCACTTAGCAATAGTTTTACATTGACCCGCGGCGAGAAGATTCACAGTCCGCACACGTCACCGAAAATAAGCCGAAAAACTCCGATTCCGTTCATGAGCTCTGTGGCGAGCGAGCAACAAATTTTCTCGTTATCAACGGCGGTGATGACAACAACAACAACAACGACGGCGGCGGCGGCAGCAGCTGCAGCAGCAGCGAGCAAGCCAATCTCGTCATCATCCTCCATTTGTTCCTCGTCGTCATCCACCTCGTCGTCGTCGACAATGAGTTCATCGTCGCTGACAAATGCTGTCAATGTGAGCGTTCATGCGAATGGCAAGGGACCGAAGACAATTGTCGTTGCGACACCTCCAATTTGCCCCTCATCCACCGCCTCGACAACGTGCAGTGCGAGCAGAACGTCACTCATTGACTTGCCGAATGTCGAGCAGATGTCGAGCGGCAAGACAATAAATCTTCCGGCGTGTCAAGAGACGGCACCGCCCATTCCACCGAGAAAGTCGGCGATGCTCCAGCCAACGAACGACATCAACCGGCCACAGAAGCTTCCGACCGCCACCGCCAGCACTCCGCCGATTAGCCAGACAAATTCCGTTGAAAAGTGCGAGAGCTCCGAGTCGAAGGTGGCGGCGAATGTTGCCGCAGTGCCACATCTGCCGCCACCTCCACCCACCTCCTCCTCGTCTTCTTCCTCCGCTGCCACCACCGCTGTCGCCGTATCATCCTCCTCCTCCTTCACCTCACAGGCACAAGAGGAGACGGACGAAGACGAGGATTCTAATCCAATTTGCGGACCGGCCGAGACGATAAGCGGCATCATCGACACGCGCCCCATTGAGCAACGAACGAACTACATAAGCTTCGCCTCGCTCACAAATAATGTGACGACCAATTTTAATCTCGTTACGATCAATGACACATCGTCAAATGCTGCCGCAAACAACTCGTCCAACGTCTCGAACGCACCGTCGACGATGGTCGTGAATGCCGCGGCAAAGGATGCCGCATCGCTGCAGCGGGCGGAGGAGAGTAATAAAATTTCGAATACATATCTACTGAGAAGCAACCACGTGAATAACATTAACAACAACAACAACAGCAGCAGCAATAATGCCATGAACGGATCGAGTAATCACCATCAGCGACATATGTCGGTGCCGGTCGGCGGTACGCCCATAAAAACGCTGCCGACCTCCTCGTCGTCGACATTGCATGCGTCAATTAGTCAGAAAATGCCAAATAATTCGCCTCTGAGAGCGGCCGCGTCCACTTGTGCCAACACCGCCGTCCGACCCGCAGCGACGTCGACAACGAACCTCCAGCTGTACGAGAATGTCAAGATGAAGTCGGCCGGAAATCTCATCTCGCTCAACAACCTCAACAACAACAACAACAACAGCTCGAGCCACAACACCAACAACAGTTGCAGCAACGTGTCGTACGAGAACATCAACCTCGAGTACATCAATCGACTGATGAAGGAGGGCTACTCGAAGGAGAACGTCATGGCCGCGCTGTGCATCTCGCGCAACAACTTCGAAATGGCGTGCGACATTCTGCACGAGTTCGTGAGCACCAATCATCAAAAGGTCTGTGAGAGCAAACAC
Protein: 979 (aa)
MMKNLTFFSKIQCKLTDCTQQKLMTDKKTLEKTWKLMDKVVKLCQQSKMNLKNSPPFILDILPDTYQRLHLIYSKYEDQMHVLHSNEHFTVFINNLMRKCKQAIKLFKEGKMQMFDENSHYRRNLTKLSLVFSHMLSELKAIFPNGTFAGDQFRITKADAAEFWKSRFGNNTLVQWKTFRAHLSEVHPISSGLEAMALKTTIDLTCNDYISNFEFDVFTRLFQPWNTLLRNWQILAVTHPAYVAFLTYDEVKARLQKYINKAGSYVFRLSCTRLGQWAIGYVTADGEILQTIPQNKSLCQALLDGYREGFYLYPDGRPHNPDLSFAVQSPLEDHITVTQEQYELYCEMGSTFQLCKICAENDKDIRIEPCGHLLCTPCLTAWQVDSEGQGCPFCRAEIKGTEQIIVDAFDPQRQYNRNSKQKDEDHDDENEETEFNLEESSIQALSNSFTLTRGEKIHSPHTSPKISRKTPIPFMSSVASEQQIFSLSTAVMTTTTTTTAAAAAAAAAASKPISSSSSICSSSSSTSSSSTMSSSSLTNAVNVSVHANGKGPKTIVVATPPICPSSTASTTCSASRTSLIDLPNVEQMSSGKTINLPACQETAPPIPPRKSAMLQPTNDINRPQKLPTATASTPPISQTNSVEKCESSESKVAANVAAVPHLPPPPPTSSSSSSSAATTAVAVSSSSSFTSQAQEETDEDEDSNPICGPAETISGIIDTRPIEQRTNYISFASLTNNVTTNFNLVTINDTSSNAAANNSSNVSNAPSTMVVNAAAKDAASLQRAEESNKISNTYLLRSNHVNNINNNNNSSSNNAMNGSSNHHQRHMSVPVGGTPIKTLPTSSSSTLHASISQKMPNNSPLRAAASTCANTAVRPAATSTTNLQLYENVKMKSAGNLISLNNLNNNNNNSSSHNTNNSCSNVSYENINLEYINRLMKEGYSKENVMAALCISRNNFEMACDILHEFVSTNHQKVCESKH
| Type | Start | End | Length |
| CDS |
12331 |
12842 |
512 |
| CDS |
16484 |
16630 |
147 |
| CDS |
16785 |
17045 |
261 |
| CDS |
17128 |
17252 |
125 |
| CDS |
17491 |
17612 |
122 |
| CDS |
17862 |
17987 |
126 |
| CDS |
20953 |
22596 |
1644 |
| intron |
12843 |
16483 |
3641 |
| intron |
16631 |
16784 |
154 |
| intron |
17046 |
17127 |
82 |
| intron |
17253 |
17490 |
238 |
| intron |
17613 |
17861 |
249 |
| intron |
17988 |
20952 |
2965 |
Auto annotation result
| Program/Analysis | Accession | Description | Score/Expectation |
| BLASTP/NCBI-nr |
XP_556087 |
AGAP005449-PA [Anopheles gambiae str. PEST] gb|EAL39826.3| AGAP005449-PA [Anopheles gambiae str. PEST] |
0.0 |
| InterPro |
IPR024159 |
Adaptor protein Cbl, PTB domain |
|
| InterPro |
IPR017907 |
Zinc finger, RING-type, conserved site |
|
| InterPro |
IPR001841 |
Zinc finger, RING-type |
|
| InterPro |
IPR011992 |
EF-hand-like domain |
|
| InterPro |
IPR014742 |
Adaptor protein Cbl, SH2-like |
|
| InterPro |
IPR015940 |
Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote |
|
| InterPro |
IPR000980 |
SH2 domain |
|
| InterPro |
IPR024162 |
Adaptor protein Cbl |
|
| InterPro |
IPR013083 |
Zinc finger, RING/FYVE/PHD-type |
|
| InterPro |
IPR014741 |
Adaptor protein Cbl, EF hand-like |
|
| InterPro |
IPR003153 |
Adaptor protein Cbl, N-terminal helical |
|
| InterPro |
IPR009060 |
UBA-like |
|
| Gene Ontology(BP) |
GO:0007166 |
cell surface receptor linked signaling pathway |
|
| Gene Ontology(BP) |
GO:0023051 |
regulation of signaling |
|
| Gene Ontology(CC) |
GO:0005634 |
nucleus |
|
| Gene Ontology(MF) |
GO:0001784 |
phosphotyrosine binding |
|
| Gene Ontology(MF) |
GO:0005515 |
protein binding |
|
| Gene Ontology(MF) |
GO:0005509 |
calcium ion binding |
|
| Gene Ontology(MF) |
GO:0008270 |
zinc ion binding |
|
| Gene Ontology(MF) |
GO:0004871 |
signal transducer activity |
|
| Gene Ontology(MF) |
GO:0004842 |
ubiquitin-protein ligase activity |
|
| Pfam |
PF02262.11 |
CBL proto-oncogene N-terminal domain 1 |
1.1e-69 |
| Pfam |
PF02762.9 |
CBL proto-oncogene N-terminus, SH2-like domain |
2.5e-51 |
| Pfam |
PF13923.1 |
Zinc finger, C3HC4 type (RING finger) |
1.5e-08 |
| Pfam |
PF14447.1 |
Prokaryotic RING finger family 4 |
9e-05 |
| Pfam |
PF00627.26 |
UBA/TS-N domain |
0.0027 |
| Pfam |
PF02761.9 |
CBL proto-oncogene N-terminus, EF hand-like domain |
1.6e-44 |
| Pfam |
PF13639.1 |
Ring finger domain |
2.7e-05 |
| Pfam |
PF00097.20 |
Zinc finger, C3HC4 type (RING finger) |
1.5e-08 |
| Pfam |
PF13920.1 |
Zinc finger, C3HC4 type (RING finger) |
2.5e-10 |
Expression level (RPKM)
Paralog/Ortholog genes
Paralogous genes
Orthologous genes
| Species |
Gene ID |
| H. sapiens |
ENSP00000264122 |
| H. sapiens |
ENSP00000384816 |
| P. humanus |
PHUM394550-PA |
| M. musculus |
ENSMUSG00000022637 |
| S. invicta |
SI2.2.0_10377 |
| H. sapiens |
ENSP00000384938 |
| N. vitripennis |
NV16764-PA |
| C. quinquefasciatus |
CPIJ012193 |
| M. musculus |
ENSMUSG00000034342 |
| B. mori |
BGIBMGA013313-TA |
| P. vanderplanki |
Pv.14004 |
| T. castaneum |
TC003318 |
| H. sapiens |
ENSP00000377598 |
| A. aegypti |
AAEL009739 |
| A. mellifera |
GB16551-PA |
| H. sapiens |
ENSP00000377595 |
| D. melanogaster |
FBgn0020224 |
| H. melpomene |
HMEL003401-PA |
| A. gambiae |
AGAP005449 |
| D. plexippus |
DPOGS202430PA |
| H. sapiens |
ENSP00000264033 |